Atom-Economical Synthesis of 2-Aminoimidazoles via [3+2] Annulation Catalyzed by Titanacarborane Monoamide
Yang Wang, Hao Shen, Zuowei Xie*
*Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, P. R. of China, Email: zxiecuhk.edu.hk
Y. Wang, H. Shen, Z. Xie, Synlett, 2011, 969-973.
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Reactions of propargylamines with carbodiimides, in the presence of 5 mol% of the titanacarborane monoamide [σ:η1:η5-(OCH2)(Me2NCH2)C2B9H9]Ti(NMe2), afford a new class of substituted 2-aminoimidazoles via [3+2] annulation in good to excellent yields. A possible reaction mechanism is proposed.
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catalysis, heterocycles, hydroamination, imidazoles, metallacarborane