Tandem Catalysis: From Alkynoic Acids and Aryl Iodides to 1,2,3-Triazoles in One Pot
Andrej Kolarovič*, Michael Schnürch and Marko D. Mihovilovic
*Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinskeho 9, 81237 Bratislava, Slovak Republic, Email: andrej.kolarovicstuba.sk
A. Kolarovič, M. Schnürch, M. D. Mihovilovic, J. Org. Chem., 2011, 76, 2613-2618.
A tandem catalysis protocol based on decarboxylative coupling of alkynoic acids and 1,3-dipolar cycloaddition of azides avoids usage of gaseous or highly volatile terminal alkynes, reduces handling of potentially unstable and explosive azides to a minimum, and furnishes various functionalized 1,2,3-triazoles in excellent yields and a very good purity without the need for additional purification.
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Click Chemistry, 1,2,3-Triazoles, Multicomponent Reactions