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Nickel-Catalyzed Reductive Cyclization of Organohalides

Hyejin Kim and Chulbom Lee*

*Department of Chemistry, Seoul National University, Seoul 151-747, South Korea, Email: chulbomsnu.ac.kr

H. Kim, C. Lee, Org. Lett., 2011, 13, 2050-2053.

DOI: 10.1021/ol200455n (free Supporting Information)


Abstract

A mild and convenient free-radical cyclization of organohalides in the presence of a NiCl2 • DME/Pybox complex as the catalyst and zinc powder in methanol efficiently gives carbo-, oxa-, and azacycles as products in high yields from unsaturated alkyl halides.

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Key Words

tetrahydrofurans, tetrahydropyrans, pyrrolidines, indanes, zinc


ID: J54-Y2011-1120