A Green Chemistry Method for the Regeneration of Carbonyl Compounds from Oximes by Using Cupric Chloride Dihydrate as a Recoverable Promoter for Hydrolysis

Na Quan, Xiao-Xin Shi*, Liang-Deng Nie, Jing Dong, Rui-Heng Zhu

*Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, 130 Mei-Long Road, Shanghai 200237, P. R. of China, Email: xxshiecust.edu.cn

N. Quan, X.-X. Shi, L.-D. Nie, J. Dong, R.-H. Zhu, Synlett, 2011, 1028-1032.

DOI: 10.1055/s-0030-1259730

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Abstract

Carbonyl compounds were obtained in very good yields after treatment of oximes with 2 molar equivalent of CuCl₂ • 2 H₂O at reflux in acetonitrile and water (4:1). In addition, cupric salt was readily recovered in an almost quantitative yield via the complete precipitation of Cu(OH)₂ • 2 H₂O.

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Key Words

carbonyl compounds, oxime, hydrolysis (aldehydes, ketones), cupric chloride, green chemistry

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ID: J60-Y2011-1130