A Green Chemistry Method for the Regeneration of Carbonyl Compounds from Oximes by Using Cupric Chloride Dihydrate as a Recoverable Promoter for Hydrolysis
Na Quan, Xiao-Xin Shi*, Liang-Deng Nie, Jing Dong, Rui-Heng Zhu
*Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, 130 Mei-Long Road, Shanghai 200237, P. R. of China, Email: xxshiecust.edu.cn
N. Quan, X.-X. Shi, L.-D. Nie, J. Dong, R.-H. Zhu, Synlett, 2011, 1028-1032.
DOI: 10.1055/s-0030-1259730 (free Supporting Information)
Carbonyl compounds were obtained in very good yields after treatment of oximes with 2 molar equivalent of CuCl2 • 2 H2O at reflux in acetonitrile and water (4:1). In addition, cupric salt was readily recovered in an almost quantitative yield via the complete precipitation of Cu(OH)2 • 2 H2O.
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