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1,7-Palladium Migration via C-H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of Benzotriazoles

Jun Zhou, Jianjun He, Binjie Wang, Weijun Yang, and Hongjun Ren*

*Department of Chemistry, Zhejiang University, 38 Zheda Road, Hangzhou 310027, P. R. China, Email:

J. Zhou, J. He, B. Wang, W. Yang, H. Ren, J. Am. Chem. Soc., 2011, 133, 6868-6870.

DOI: 10.1021/ja2007438 (free Supporting Information)


A 1,7-palladium migration-cyclization-dealkylation sequence for the regioselective synthesis of benzotriazoles proceed in excellent yields with high regioselectivities. The mechanism of the reaction has also been investigated.

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ID: J48-Y2011-1220