Reduction of Carboxylic Acids Using Esters of Benzotriazole as High-Reactivity Intermediates
José Antonio Morales-Serna, Eréndira García-Ríos, Jorge Bernal, Ehecatl Paleo, Rubén Gaviño, Jorge Cárdenas*
*Instituto de Química, Universidad Nacional Autónoma de
México, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, México D.F.,
México, Email: rjcp
unam.mx
J. A. Morales-Serna, E. García-Rios, J. Bernal, E. Paleo, R. Gaviño, J. Cárdenas, Synthesis, 2011, 1375-1382.
DOI: 10.1055/s-0030-1259988
Abstract
A simple and practical protocol for the reduction of carboxylic acids via in situ formation of hydroxybenzotriazole esters followed by reaction with sodium borohydride gives the corresponding alcohols. The reaction proceeds with excellent yields in the presence of water.
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Key Words
alcohols, carboxylic acids, reduction, benzotriazole esters, carbodiimide, sodium borohydride
ID: J66-Y2011-1230
