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Iron-Catalyzed Stereospecific Olefin Synthesis by Direct Coupling of Alcohols and Alkenes with Alcohols

Zhong-Quan Liu*, Yuexia Zhang, Lixing Zhao, Zejiang Li, Jiantao Wang, Huajie Li and Long-Min Wu

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou Gansu 730000, P. R. China, Email:

Z.-Q. Liu, Y. Zhang, L. Zhao, Z. Li, J. Wang, H. Li, L.-M. Wu, Org. Lett., 2011, 13, 2208-2211.

DOI: 10.1021/ol200372y


An efficient Fe(III)-catalyzed direct coupling of alkenes with alcohols and cross-coupling of alcohols with alcohols gives the corresponding substituted (E)-alkenes stereospecifically. Mild conditions, atom efficiency, environmental soundness, and stereospecificity are features that make this procedure very attractive. Additionally, this reaction could be scaled up.

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Key Words

benzylation, vinylation

ID: J54-Y2011-1240