Organic Chemistry Portal



"Greener" Friedel-Crafts Acylations: A Metal- and Halogen-Free Methodology

Mark C. Wilkinson*

*API Chemistry & Analysis, Product Development, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Email:

M. C. Wilkinson, Org. Lett., 2011, 13, 2232-2235.

DOI: 10.1021/ol200482s

see article for more reactions


Methanesulfonic anhydride promotes Friedel-Crafts acylations of aryl and alkyl carboxylic acids. This reagent allows the preparation of aryl ketones in good yield with minimal waste containing no metallic or halogenated components, clearly differentiating it from other available methodologies.

see article for more examples

Key Words

Friedel-Crafts Acylation, Green Chemistry

ID: J54-Y2011-1250