An Efficient Protocol for the Synthesis of 2-Phenylquinazolines Catalyzed by Ceric Ammonium Nitrate (CAN)
K. Karnakar, J. Shankar, S. Narayana Murthy, K. Ramesh, Y. V. D. Nageswar*
*Organic Chemistry Division I, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500607, India, Email: dryvdnageswargmail.com
K. Karnakar, J. Shangkar, S. N. Murthy, K. Ramesch, Y. V. D. Nageshwar, Synlett, 2011, 1089-1096.
A facile and efficient method for the synthesis of 2-phenylquinazolines from 2-aminobenzophenones and benzylamines is catalyzed by ceric ammonium nitrate (CAN)-TBHP in acetonitrile. The corresponding 2-phenylquinazolines were obtained in good to excellent yields.
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quinazolines, 2-aminobenzophenones, benzylamines, ceric ammonium nitrate, tert-butyl hydroperoxide, acetonitrile