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An Improved Larock Synthesis of Quinolines via a Heck Reaction of 2-Bromoanilines and Allylic Alcohols

Matthew T. Stone*

*Department of Chemistry and Novartis Center for Continuous Manufacturing, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email:

M. T. Stone, Org. Lett., 2011, 13, 2326-2329.

DOI: 10.1021/ol200579a


A modified Larock method enables a one-pot synthesis of substituted quinolines via a Heck reaction of 2-bromoanilines and allylic alcohols followed by dehydrogenation with diisopropyl azodicarboxylate (DIAD).

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Key Words

Quinolines, DIAD

ID: J54-Y2011-1330