An Improved Larock Synthesis of Quinolines via a Heck Reaction of 2-Bromoanilines and Allylic Alcohols
Matthew T. Stone*
*Department of Chemistry and Novartis Center for Continuous Manufacturing, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: matthew.stonemerckgroup.com
M. T. Stone, Org. Lett., 2011, 13, 2326-2329.
DOI: 10.1021/ol200579a (free Supporting Information)
A modified Larock method enables a one-pot synthesis of substituted quinolines via a Heck reaction of 2-bromoanilines and allylic alcohols followed by dehydrogenation with diisopropyl azodicarboxylate (DIAD).
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