Copper(I) Iodide Catalyzed Cross-Coupling Reaction of Terminal Alkynes with 1-Bromoalkynes: A Simple Synthesis of Unsymmetrical Buta-1,3-diynes
Shihua Wang, Lin Yu, Pinhua Li, Lingguo Meng, Lei Wang*
*Department of Chemistry, Huaibei Normal University, Huaibei,
Anhui 235000, P. R. of China, Email:
leiwang
chnu.edu.cn
S. Wang, L. Yu, P. Li, L. Meng, L. Wang, Synthesis, 2011, 1541-1546.
Abstract
A cross-coupling of terminal alkynes with 1-bromoalkynes in the presence of copper(I) iodide and tris(o-tolyl)phosphine enables the synthesis of unsymmetrical buta-1,3-diynes in good yields under simple and mild reaction conditions. The scope and limitations of the cross-coupling reaction were investigated.
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Key Words
alkynes, catalysis, cross-coupling, alkadiynes, diynes, Cadiot-Chodkiewicz Coupling
ID: J66-Y2011-1350
