Organic Chemistry Portal



Ligand-Free Ag(I)-Catalyzed Carboxylation of Terminal Alkynes with CO2

Xiao Zhang, Wen-Zhen Zhang*, Xiang Ren, Lin-Lin Zhang and Xiao-Bing Lu*

*State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China, Email:,

X. Zhang, W.-Z. Zhang, X. Ren, L.-L. Zhang, X.-B. Lu, Org. Lett., 2011, 13, 2402-2405.

DOI: 10.1021/ol200638z (free Supporting Information)


A convenient approach to selectively prepare a wide range of functionalized propiolic acids was developed by AgI-catalyzed carboxylation of terminal alkynes using carbon dioxide as carboxylative agent under ligand-free conditions.

see article for more examples

Key Words

Carboxylation, Alkynylation

ID: J54-Y2011-1410