Ligand-Free Ag(I)-Catalyzed Carboxylation of Terminal Alkynes with CO₂

Xiao Zhang, Wen-Zhen Zhang*, Xiang Ren, Lin-Lin Zhang and Xiao-Bing Lu*

*State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China, Email: zhangwzdlut.edu.cn, lxb-1999163.com

X. Zhang, W.-Z. Zhang, X. Ren, L.-L. Zhang, X.-B. Lu, Org. Lett., 2011, 13, 2402-2405.

DOI: 10.1021/ol200638z

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Abstract

A convenient approach to selectively prepare a wide range of functionalized propiolic acids was developed by AgI-catalyzed carboxylation of terminal alkynes using carbon dioxide as carboxylative agent under ligand-free conditions.

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Key Words

Carboxylation, Alkynylation

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ID: J54-Y2011-1410