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A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides

Emilie Racine, Florian Monnier*, Jean-Pierre Vors and Marc Taillefer*

*Ecole Nationale Supérieure de Chimie de Montpellier, Institut Charles Gerhardt, CNRS UMR 5253, AM2N, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 05, France, Email:,

E. Racine, F. Monnier, J.-P. Vors, M. Taillefer, Org. Lett., 2011, 13, 2818-2821.

DOI: 10.1021/ol200750p

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The N-arylation of aromatic and aliphatic secondary acyclic amides as poor nucleophiles has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides have been obtained in good to excellent yields.

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ID: J54-Y2011-1540