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Hydrazone-Promoted Sonogashira Coupling Reaction with Aryl Bromides at Low Palladium Loadings

Takashi Mino*, Saori Suzuki, Kiminori Hirai, Masami Sakamoto, Tsutomu Fujita

*Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email:

T. Mino, S. Suzuki, K. Hirai, M. Sakamoto, T. Fujita, Synlett, 2011, 1277-1280.

DOI: 10.1055/s-0030-1260535 (free Supporting Information)


The Sonogashira coupling reaction of aryl bromides with various terminal alkynes in DMSO at 125˚C gave internal alkynes in good yields using low catalyst loadings of Pd(acac)2 with hydrazone as a ligand and CuI as the co-catalyst.

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Key Words

palladium, catalysis, Sonogashira coupling reaction, hydrazone

ID: J60-Y2011-1560