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Syntheses of α-Pyrones Using Gold-Catalyzed Coupling Reactions

Tuoping Luo, Mingji Dai, Shao-Liang Zheng and Stuart L. Schreiber*

*Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States, Email:

T. Luo, M. Dai, S.-L. Zheng, S. L. Schreiber, Org. Lett., 2011, 13, 2834-2836.

DOI: 10.1021/ol200794w

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Sequential activation of terminal alkynes and propiolic acids by gold(I) catalysts yields α-pyrones in good yields. Novel cascade reactions involving propiolic acids are reported that give rise to α-pyrones with different substitution patterns.

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ID: J54-Y2011-1590