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Copper(I)-Catalyzed Synthesis of Pyrazoles from Phenylhydrazones and Dialkyl Ethylenedicarboxylates in the Presence of Bases

Chaowei Ma, Yanmei Li, Ping Wen, Rulong Yan, Zhiyong Ren, Guosheng Huang*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Email:

C. Ma, Y. Li, P. Wen, R. Yan, Z. Ren, G. Huang, Synlett, 2011, 1321-1323.

DOI: 10.1055/s-0030-1260522


An easy and efficient copper-catalyzed reaction for the synthesis of polysubstituted pyrazoles from phenylhydrazones and dialkyl ethylenedicarboxylates tolerates a range of functionalities, and the corresponding adducts can be obtained in moderate to good yields.

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Key Words

heterocycles, copper catalysis, hydrazones, dialkyl ethylenedicarboxylates, pyrazoles

ID: J60-Y2011-1680