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A Regioselective and High-Yielding Method for Formaldehyde Inclusion in the 3CC Groebke-Blackburn-Bienaymé Reaction: One-Step Access to 3-Aminoimidazoazines

Anuj Sharma, Hong-yu Li*

*College of Pharmacy, Department of Pharmacoloy/Toxicology, The University of Arizona, Tucson, AZ 85721, USA, Email: hongyulipharmacy.arizona.edu

A. Sharma, H.-y. Li, Synlett, 2011, 1407-1412.

DOI: 10.1055/s-0030-1260568


Abstract

In a regioselective and high-yielding Groebke-Blackburn-Bienaymé reaction, glyoxylic acid is used as formaldehyde equivalent leading to a regioselective, mild, convenient, and effective synthesis of 3-aminoalkyl imidazoazines.

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Key Words

Groebke-Blackburn-Bienaymé, multicomponent reactions, imidazo[1,2-a]pyridines, benzo-fused N-Heterocycles, aminoimidazoazines, formaldehyde, glyoxylic acid


ID: J60-Y2011-1700