Organic Chemistry Portal



Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates

Amruta Joshi-Pangu, Chao-Yuan Wang and Mark R. Biscoe*

*Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, New York 10031, United States, Email:

A. Joshi-Pangu, C.-Y. Wang, M. R. Biscoe, J. Am. Chem. Soc., 2011, 133, 8478-8481.

DOI: 10.1021/ja202769t (free Supporting Information)

see article for more reactions


A Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides is extremely general for a wide range of electrophiles and generally occurs with little isomerization. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.

see article for more examples

Key Words

Kumada Coupling, Arenes

ID: J48-Y2011-1720