An Efficient Copper-Catalyzed Etherification of Aryl Halides
Jinkun Huang*, Ying Chen, Johann Chan, Mike L. Ronk, Robert D. Larsen, Margaret M. Faul
*Chemical Process R&D, Amgen Inc., One Amgen Center Drive,
Thousand Oaks, CA 91320, USA, Email: jhuang
amgen.com
J. Huang, Y. Chen, J. Chan, M. L. Ronk, R. D. Larsen, M. M. Faul, Synlett, 2011, 1419-1422.
DOI: 10.1055/s-0030-1260761
Abstract
In an efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols, the key to a successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the corresponding alcohol as solvent.
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Key Words
ligand-free, copper, etherification, aryl halides, Ullmann Coupling
ID: J60-Y2011-1730
