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An Efficient Copper-Catalyzed Etherification of Aryl Halides

Jinkun Huang*, Ying Chen, Johann Chan, Mike L. Ronk, Robert D. Larsen, Margaret M. Faul

*Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA, Email:

J. Huang, Y. Chen, J. Chan, M. L. Ronk, R. D. Larsen, M. M. Faul, Synlett, 2011, 1419-1422.

DOI: 10.1055/s-0030-1260761


In an efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols, the key to a successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the corresponding alcohol as solvent.

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Key Words

ligand-free, copper, etherification, aryl halides, Ullmann Coupling

ID: J60-Y2011-1730