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Synthesis of 2-Mercaptobenzothiazoles via DBU-Promoted Tandem Reaction of o-Haloanilines and Carbon Disulfide

Fei Wang, Shangjun Cai, Zhipeng Wang and Chanjuan Xi*

*Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, Email:

F. Wang, S. Cai, Z. Wang, C. Xi, Org. Lett., 2011, 13, 3202-3205.

DOI: 10.1021/ol2011105


An efficient strategy for the synthesis of various 2-mercaptobenzothiazole derivatives proceeds from o-haloaniline derivatives and carbon disulfide via a tandem reaction in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to afford the corresponding 2-mercaptobenzothiazole derivatives in good yields.

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ID: J54-Y2011-1770