A Novel Recyclable Organocatalytic System for the Highly Asymmetric Michael Addition of Aldehydes to Nitroolefins in Water
Dhruba Sarkar, Ramesh Bhattarai, Allan D. Headley*, Bukuo Ni*
*Department of Chemistry, Texas A & M University-Commerce, Commerce, Texas 75429-3011, USA, Email: allan_headleytamu-commerce.edu, bukuo_nitamu-commerce.edu
D. Sarkar, R. Bhattarai, A. D. Headley, B. Ni, Synthesis, 2011, 1993-1997.
A strategy for the asymmetric Michael addition of aldehydes to nitroolefins with a catalytic system of an organocatalyst in combination with ionic-liquid-supported benzoic acid gives excellent diastereo- and enantioselectivities. A notable feature of this organocatalytic system is that the catalyst can be recycled more than 12 times without significant loss of enantioselectivity.
see article for more examples
Z. Zheng, B. L. Perksin, B. Ni, J. Am. Chem. Soc., 2010, 132, 50-51.