Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C-N Cross-Coupling Reactions
Simon Breitler, Nathan J. Oldenhuis, Brett P. Fors and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwal
mit.edu
S. Breitler, N. J. Oldenhuis, B. P. Fors, S. L. Buchwald, Org. Lett., 2011, 13, 3262-3265.
DOI: 10.1021/ol201210t
see article for more reactions
Abstract
Pd-catalyzed arylation of ureas enables a facile synthesis of an array of unsymmetrical N,N′-diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.
see article for more examples
Key Words
ID: J54-Y2011-1800
