Zirconyl Chloride: An Efficient, Water-Tolerant, and Reusable Catalyst for the Synthesis of N-Methylamides

Dhrubajyoti Talukdar, Lakhinath Saikia, Ashim Jyoti Thakur*

*Department of Chemical Sciences, Tezpur University, Napaam 784028, India, Email: ashimtezu.ernet.in

D. Talukdar, L. Saikia, A. J. Thakur, Synlett, 2011, 1597-1601.

DOI: 10.1055/s-0030-1260796

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Abstract

ZrOCl₂ • 8 H₂O is a highly effective, water-tolerant, and reusable catalyst for the direct condensation of carboxylic acids and N,N′-dimethylurea under microwave irradiation to give the corresponding N-methylamides in moderate to excellent yields. ZrOCl₂ • 8 H₂O is a useful green catalyst due to its low toxicity, easy availability, low cost, ease of handling, easy recovery, good activity, and reusability.

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Key Words

zirconium oxychloride octahydrate, carboxylic acid, N,N′-dimethylurea, N-methyl amide, amides, microwave synthesis, green chemistry

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ID: J60-Y2011-1940