Ni(II)/Zn Catalyzed Reductive Coupling of Aryl Halides with Diphenylphosphine Oxide in Water

Xinghua Zhang, Huizhi Liu, Xiaomei Hu, Guo Tang*, Jun Zhu* and Yufen Zhao

*Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China, Email: t12g21xmu.edu.cn, jun.zhuxmu.edu.cn

X. Zhang, H. Liu, X. Hu, G. Tang, J. Zhu, Y. Zhao, Org. Lett., 2011, 13, 3478-3481.

DOI: 10.1021/ol201141m

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Abstract

NiCl₂ • 6 H₂O/Zn catalyzes the cross-coupling of aryl halides with diphenylphosphine oxide (Ph₂P(O)H) and (R_P)-(−)-menthyl benzylphosphinate in water under relatively mild conditions.

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Key Words

phosphine oxides

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ID: J54-Y2011-1950