An Efficient, Simple, and Scaleable Domino Reaction to Diverse N-(1-Oxo-1H-inden-2-yl)benzamides Catalyzed by HPW@nano-SiO2 under Microwave Irradiation
Mahboubeh Rostami, Ahmad R. Khosropour*, Valiollah Mirkhani, Iraj Mohammadpoor-Baltork, Majid Moghadam, Shahram Tangestaninejad
*Catalysis Division, Department of Chemistry, Faculty of
Science, University of Isfahan, Isfahan 81746-7344, Iran, Email: Khosropour
chem.ui.ac.ir
M. Rostami, A. R. Khosropour, V. Mirkhani, I. Mohammadpoor-Baltork, M. Moghadam, S. Tangestaninejad, Synlett, 2011, 1677-1682.
DOI: 10.1055/s-0030-1260938
Abstract
A facile, efficient, and large-scale strategy for the synthesis of N-(1-Oxo-1H-inden-2-yl)benzamide derivatives via domino reaction between aryl aldehydes, hippuric acid, and acetic anhydride is catalyzed by HPW@nano-SiO2 under microwave irradiation. The reaction conditions are very simple and offer convenient isolation of the product. Moreover, the catalyst can be re-used up to five times after simple filtration.
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Key Words
tandem reaction, indenones, heterogeneous catalyst, microwave synthesis, nanosilica, heteropoly acid
ID: J60-Y2011-1990
