Organocatalytic Decarboxylative Doebner-Knoevenagel Reactions between Arylaldehydes and Monoethyl Malonate Mediated by a Bifunctional Polymeric Catalyst
Jinni Lu, Patrick H. Toy*
*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. of China, Email: phtoyhku.hk
J. Lu, P. H. Toy, Synlett, 2011, 1723-1726.
DOI: 10.1055/s-0030-1260808 (free Supporting Information)
A bifunctional polystyrene bearing both DMAP and piperidine groups is an effective organocatalyst for decarboxylative Doebner-Knoevenagel reactions of arylaldehydes and monoethyl malonate to give E-cinnamates in high yields. A synergistic effect obtained by co-locating the two different catalytic amine groups on the same polymer backbone has been detected.
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