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Synthesis of Substituted Pyrazoles via Tandem Cross-Coupling/Electrocyclization of Enol Triflates and Diazoacetates

David J. Babinski, Hector R. Aguilar, Raymond Still and Doug E. Frantz*

*Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States, Email: doug.frantzutsa.edu

D. J. Babinski, H. R. Aguilar, R. Still, D. E. Frantz, J. Org. Chem., 2011, 76, 5915-5923.

DOI: 10.1021/jo201042c (free Supporting Information)



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Abstract

A tandem catalytic cross-coupling/electrocyclization allows the conversion of differentially substituted acyclic and cyclic enol triflates and an elaborated set of diazoacetates to provide the corresponding 3,4,5-trisubstituted pyrazoles with a high degree of structural complexity.

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Key Words

Pyrazoles


ID: J42-Y2011-2070