Synthesis of Substituted Pyrazoles via Tandem Cross-Coupling/Electrocyclization of Enol Triflates and Diazoacetates
David J. Babinski, Hector R. Aguilar, Raymond Still and Doug E. Frantz*
*Department of Chemistry, The University of Texas at San
Antonio, San Antonio, Texas 78249, United States, Email: doug.frantz
utsa.edu
D. J. Babinski, H. R. Aguilar, R. Still, D. E. Frantz, J. Org. Chem., 2011, 76, 5915-5923.
DOI: 10.1021/jo201042c
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Abstract
A tandem catalytic cross-coupling/electrocyclization allows the conversion of differentially substituted acyclic and cyclic enol triflates and an elaborated set of diazoacetates to provide the corresponding 3,4,5-trisubstituted pyrazoles with a high degree of structural complexity.
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Key Words
ID: J42-Y2011-2070
