Ligand Effects on Negishi Couplings of Alkenyl Halides
Arkady Krasovskiy and Bruce H. Lipshutz*
*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu
A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3818-3821.
DOI: 10.1021/ol2010165 (free Supporting Information)
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The stereochemical outcome of Negishi coulings of Z-alkenyl halides is highly ligand dependent. A modified method solves the stereochemical issue and significantly improves yields of Negishi couplings in general even at ambient temperature.
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A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3822-3825.
A. Krasovskiy, C. Duplais, B. H. Lipshutz, Org. Lett., 2010, 12, 4742-4744.