Ligand Effects on Negishi Couplings of Alkenyl Halides
Arkady Krasovskiy and Bruce H. Lipshutz*
*Department of Chemistry & Biochemistry, University of
California, Santa Barbara, California 93106, United States, Email: lipshutz
chem.ucsb.edu
A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3818-3821.
DOI: 10.1021/ol2010165
see article for more reactions
Abstract
The stereochemical outcome of Negishi coulings of Z-alkenyl halides is highly ligand dependent. A modified method solves the stereochemical issue and significantly improves yields of Negishi couplings in general even at ambient temperature.
see article for more examples
Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings
A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3822-3825.
A. Krasovskiy, C. Duplais, B. H. Lipshutz, Org. Lett., 2010, 12, 4742-4744.
Key Words
ID: J54-Y2011-2090
