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Ligand Effects on Negishi Couplings of Alkenyl Halides

Arkady Krasovskiy and Bruce H. Lipshutz*

*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu

A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3818-3821.

DOI: 10.1021/ol2010165


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Abstract

The stereochemical outcome of Negishi coulings of Z-alkenyl halides is highly ligand dependent. A modified method solves the stereochemical issue and significantly improves yields of Negishi couplings in general even at ambient temperature.

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Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings

A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3822-3825.

Stereoselective Negishi-like Couplings Between Alkenyl and Alkyl Halides in Water at Room Temperature

A. Krasovskiy, C. Duplais, B. H. Lipshutz, Org. Lett., 2010, 12, 4742-4744.


Key Words

Negishi Coupling, Alkenes


ID: J54-Y2011-2090