Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings
Arkady Krasovskiy and Bruce H. Lipshutz*
*Department of Chemistry & Biochemistry, University of
California, Santa Barbara, California 93106, United States, Email: lipshutz
chem.ucsb.edu
A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3822-3825.
DOI: 10.1021/ol201307y
Abstract
N-Methyimidazole as the key additive enables high yielding stereo- and chemoselective Pd-catalyzed cross-couplings of alkenyl iodides and bromides with primary and secondary alkyl zinc iodides in THF at room temperature.
see article for more examples
Ligand Effects on Negishi Couplings of Alkenyl Halides
A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3818-3821.
Key Words
ID: J54-Y2011-2110
