Synthesis and Suzuki-Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Halides
Gary A. Molander* and Inji Shin
*Roy and Diana A. Vagelos Laboratories, Department of
Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323,
United States, Email: gmolandr
sas.upenn.edu
G. A. Molander, I. Shin, Org. Lett., 2011, 13, 3956-3959.
DOI: 10.1021/ol2014768
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Abstract
Suzuki-Miyaura cross-coupling reactions of Boc-protected aminomethyltrifluoroborate with a variety of both aryl and hetaryl chlorides gives aminomethylated arenes in very good yields. Potassium Boc-protected aminomethyltrifluoroborate can successfully be synthesized through a one-pot process.
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Scope of Aminomethylations via Suzuki-Miyaura Cross-Coupling of Organotrifluoroborates
G. A. Molander, P. E. Gormisky, D. L. Sandrock, J. Org. Chem., 2008, 73, 2052-2057.
Key Words
ID: J54-Y2011-2130
