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Palladium-Catalyzed C-S Coupling: Access to Thioethers, Benzo[b]thiophenes, and Thieno[3,2-b]thiophenes

Marius Kuhn, Florian C. Falk and Jan Paradies*

*Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, D-76131 Karlsruhe, Germany, Email:

M. Kuhn, F. C. Falk, J. Paradies, Org. Lett., 2011, 13, 4100-4103.

DOI: 10.1021/ol2016093

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Thiourea can be used as a cheap and easy to handle dihydrosulfide surrogate in C-S bond formation/cross-coupling/cyclization domino reactions. Structurally important biarylthioether, benzo[b]thiophenes, and thieno[3,2-b]thiophene scaffolds are provided in high yield.

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Key Words


ID: J54-Y2011-2210