Transition-Metal-Free Alkynylation of Aryl Chlorides
Thanh Truong and Olafs Daugulis*
*Department of Chemistry, University of Houston, Houston,
Texas 77204-5003, United States, Email: olafs
uh.edu
T. Truong, O. Daugulis, Org. Lett., 2011, 13, 4172-4175.
DOI: 10.1021/ol2014736
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Abstract
The use of TMPLi base in a pentane/THF mixture at 25°C or use of a metal alkoxide base in dioxane at elevated temperature enable base-mediated, transition-metal-free alkynylations of aryl chlorides that proceed via benzyne intermediates. Fluoro, trifluoromethyl, silyl, cyano, and alcohol functionalities are compatible with the reaction conditions.
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Key Words
ID: J54-Y2011-2260
