A Facile Synthesis of α-Fluoro Ketones Catalyzed by [Cp*IrCl₂]₂

Nanna Ahlsten, Agnieszka Bartoszewicz, Santosh Agrawal, Belén Martín-Matute*

*Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden, Email: belenorgan.su.se

N. Ahlsten, A. Bartoszewicz, S. Agrawal, B. Martín-Matute, Synthesis, 2011, 2600-2608.

DOI: 10.1055/s-0030-1260130

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Abstract

Allylic alcohols are isomerized into enolates (enols) by [Cp*IrCl₂]₂. A subsequent reaction with Selectfluor present in the reaction media produces α-fluoro ketones as single constitutional isomers in good yields.

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Key Words

iridium, fluorine, isomerization, alcohols, fluoro ketones, selectfluor

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ID: J66-Y2011-2360