Organic Chemistry Portal

Abstracts

Search:

Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges

Timo Leermann, Frédéric R. Leroux* and Françoise Colobert*

*Laboratoire de Stéréochimie (UMR CNRS 7509), CNRS/Université de Strasbourg (ECPM), 25 Rue Becquerel, F-67087 Strasbourg, France, Email: francoise.colobertunistra.fr, frederic.lerouxunistra.fr

T. Leermann, F. R. Leroux, F. Colobert, Org. Lett., 2011, 13, 4479-4481.

DOI: 10.1021/ol2016252 (free Supporting Information)


see article for more reactions

Abstract

A general and convenient protocol for the electrophilic borylation of aryl Grignard reagents prepared from arylbromides by direct insertion of magnesium in the presence of LiCl or by Mg/Br exchange with iPrMgCl·LiCl enables the synthesis of various aryl boronic acids in a straightforward manner in excellent yields at 0°C.

see article for more examples



Key Words

arylboronic acids


ID: J54-Y2011-2380