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Unmodified Nano-Powder Magnetite or Iron(III) Oxide Catalyze the Easy and Fast Synthesis of 4-Substituted-4H-Pyrans

Rafael Cano, Diego J. Ramón*, Miguel Yus

*Departamento Química Orgánica and Instituto de Síntesis Orgánica, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain, Email:

R. Cano, D. J. Ramón, M. Yus, Synlett, 2011, 2017-2019.

DOI: 10.1055/s-0030-1261162 (free Supporting Information)


Inexpensive and commercially available nano-powder magnetite or iron(III) oxide can be used as catalyst in a new, straightforward, and fast protocol for the construction of 4-substituted-4H-pyrans. The reaction implies a tandem process, involving an aldol condensation, a Michael-type addition, and a dehydrating annulation.

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Key Words

annulation, heterocycles, heterogeneous catalysis, iron, pyrans

ID: J60-Y2011-2430