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A Useful, Reliable and Safer Protocol for Hydrogenation and the Hydrogenolysis of O-Benzyl Groups: The In Situ Preparation of an Active Pd0/C Catalyst with Well-Defined Properties

François-Xavier Felpin*, Eric Fouquet

*Université de Nantes, CNRS UMR 6230, CEISAM, UFR des Sciences et des Techniques, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France, Email:

F.-X. Felpin, E. Fouquet, Chem. Eur. J., 2010, 12440-12445.

DOI: 10.1002/chem.201001377


In situ preparation of an active Pd/C catalyst from Pd(OAc)2 and charcoal in methanol enables a simple, highly reproducible protocol for the hydrogenation of alkenes and alkynes and for the hydrogenolysis of O-benzyl ethers. Mild reaction conditions and low catalyst loadings, as well as the absence of contamination of the product by palladium residues, make this a sustainable, useful process.

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A Sustainable Procedure Combining the Advantages of Both Homogeneous and Heterogeneous Catalysis for the Heck-Matsuda Reaction

C. Rossy, E. Fouquet, F.-X. Felpin, Synthesis, 2012, 44, 37-41.

Key Words

hydrogenation (of alkenes, of alkynes), hydrogenolysis (benzyl esters, Cbz-protected amines), palladium, charcoal, green chemistry, hydrogen

ID: JXX-Y2010-3600