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Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids

SeungWon Chung, Daniel P. Uccello, Huiwon Choi, Justin I. Montgomery, Jinshan Chen*

*Groton Laboratories, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA, Email: michael.j.chenpfizer.com

S. Chung, D. P. Uccello, H. Choi, J. I. Montgomery, J. Chen, Synlett, 2011, 2072-2074.

DOI: 10.1055/s-0030-1260982 (free Supporting Information)


Abstract

Carboxylic acids are converted into amides in moderate to high yields in the presence of a stoichiometric amount of trimethylaluminium and amines in toluene at 90˚C after 1 hour.

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Key Words

amide, amidation, trimethylaluminium, carboxylic acid, Lewis acid


ID: J60-Y2011-2510