Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids
SeungWon Chung, Daniel P. Uccello, Huiwon Choi, Justin I. Montgomery, Jinshan Chen*
*Groton Laboratories, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA, Email: michael.j.chenpfizer.com
S. Chung, D. P. Uccello, H. Choi, J. I. Montgomery, J. Chen, Synlett, 2011, 2072-2074.
DOI: 10.1055/s-0030-1260982 (free Supporting Information)
Carboxylic acids are converted into amides in moderate to high yields in the presence of a stoichiometric amount of trimethylaluminium and amines in toluene at 90˚C after 1 hour.
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amide, amidation, trimethylaluminium, carboxylic acid, Lewis acid