Copper-Catalyzed β-Boration of α,β-Unsaturated Carbonyl Compounds with Tetrahydroxydiborane
Gary A. Molander* and Silas A. McKee
*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States, Email: gmolandrsas.upenn.edu
G. A. Molander, S. A. McKee, Org. Lett., 2011, 13, 4648-4687.
DOI: 10.1021/ol201900d (free Supporting Information)
A copper-catalyzed β-boration of α,β-unsaturated carbonyl compounds with tetrahydroxydiborane allows direct, efficient access to boronic acids and their derivatives. Various α,β-unsaturated amides, ketones and esters are converted to the corresponding β-trifluoroborato compounds in good to excellent yields.
see article for more examples
G. A. Molander, D. E. Petrillo, Org. Lett., 2008, 10, 1795-1798.