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Ir(III)-Catalyzed Room-Temperature Synthesis of Multisubstituted Benzofurans Initiated by C-H Activation of α-Aryloxy Ketones

Takanori Shibata*, Yu-ki Hashimoto, Maiko Otsuka, Kyoji Tsuchikama, Kohei Endo

*Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Okubo, Shinjuku, Tokyo, 169-8555, Japan, Email:

T. Shibata, Y.-k. Hashimoto, M. Otsuka, K. Tsuchikama, K. Endo, Synlett, 2011, 2075-2079.

DOI: 10.1055/s-0030-1260981 (free Supporting Information)


Cyclodehydration of various α-aryloxy ketones proceeded to give various multisubstituted benzofurans by using an Ir(III) catalyst. The presence of Cu(OAc)2 and a cationic iridium complex salt, which was prepared from [Cp*IrCl2]2 and AgSbF6, realized an efficient transformation at ambient temperature.

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Key Words

C-H activation, benzofurans, cyclodehydration, iridium, room temperature

ID: J60-Y2011-2530