Hydrogenation of Azides over Copper Nanoparticle Surface Using Ammonium Formate in Water
Sabir Ahammed, Amit Saha and Brindaban C. Ranu*
*Department of organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India, Email: ocbcriacs.res.in
S. Ahammed, A. Saha, B. C. Ranu, J. Org. Chem., 2011, 76, 7235-7239.
DOI: 10.1021/jo200915h (free Supporting Information)
see article for more reactions
Aryl azides undergo clean reduction by copper nanoparticles in water in the presence of ammonium formate. The surface hydrogen on copper nanoparticles is considered to be the active reducing species. Various functionalized aryl azides and aryl sulfonyl azides are reduced to the corresponding amines with excellent chemoselectivity in high yields.
see article for more examples