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Copper(I) Iodide Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Organic Azides

Xuezhi Cheng, Yiwen Yang, Chunxiang Kuang*, Qing Yang*

*Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China, Email:,

X. Chen, Y. Yang, C. Kuang, Q. Yang, Synthesis, 2011, 2907-2912.

DOI: 10.1055/s-0030-1261030


In the presence of inexpensive copper (I) iodide as the catalyst, a series of 1,4-disubstituted 1,2,3-triazoles were synthesized in a one-pot process from anti-3-aryl-2,3-dibromopropanoic acids and organic azides in dimethyl sulfoxide.

see article for more examples

Copper(I) Iodide-Catalyzed Synthesis of 4-Aryl-1H-1,2,3-triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Sodium Azide

Y. Jiang, C. Kuang, Q. Yang, Synthesis, 2010, 4256-4260.

Key Words

cyclizations, heterocycles, azides, triazoles

ID: J66-Y2011-2550