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Microwave-Assisted and Yb(OTf)3-Promoted One-Pot Multicomponent Synthesis of Substituted Quinolines in Ionic Liquid

Anil Kumar*, V. Kameshwara Rao

*Department of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India, Email:

A. Kumar, V. K. Rao, Synlett, 2011, 2157-2162.

DOI: 10.1055/s-0030-1261200


A straightforward and efficient Yb(OTf)3 catalyzed three-component reaction of aldehydes, alkynes, and amines under microwave irradiation in an ionic liquid provides 2,4-disubstituted quinolines in excellent yield under mild reaction condition. The catalyst can be recycled up to four times.

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Key Words

microwave synthesis, ytterbium triflate, one-pot, multicomponent reactions, quinolines, ionic liquids

ID: J60-Y2011-2580