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A Simple and Efficient Protocol to 1,2,4-Substituted Pyrroles via a Sonogashira Coupling-Acid-Catalyzed Cyclization

Da Zhu, Jie Zhao, Yuxiu Wei, Hongwei Zhou*

*Department of Chemistry, Zhejiang University, (Campus Xixi), Hangzhou 310007, P. R. of China, Email:

D. Zhu, J. Zhao, Y. Wei, H. Zhou, Synlett, 2011, 2185-2186.

DOI: 10.1055/s-0030-1261175 (free Supporting Information)


A facile and efficient protocol enabled the synthesis of 1,2,4-substituted pyrrole derivatives from ready available starting materials. This type of reaction should have potential utility in organic synthesis.

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Key Words

pyrroles, Sonogashira coupling, gallium triflate, cyclization, 2-bromoallylamine

ID: J60-Y2011-2610