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CuI/TMEDA-Catalyzed Annulation of 2-Bromo Alkynylbenzenes with Na2S: Synthesis of Benzo[b]thiophenes

Lei-Lei Sun, Chen-Liang Deng, Ri-Yuan Tang and Xing-Guo Zhang*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:

L.-L. Sun, C.-L. Deng, R.-Y. Tang, X.-G. Zhang, J. Org. Chem., 2011, 76, 7546-7550.

DOI: 10.1021/jo201081v

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In the presence of CuI and TMEDA, a thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium sulfide delivers various 2-substituted benzo[b]thiophenes in good yields.

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ID: J42-Y2011-2750