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A Practical and Cost-Efficient, One-Pot Conversion of Aldehydes into Nitriles Mediated by 'Activated DMSO'

John Kallikat Augustine*, Agnes Bombrun, Rajendra Nath Atta

*Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore - 560 099, India, Email:

J. K. Augustine, A. Bombrun, R. N. Atta, Synlett, 2011, 2223-2227.

DOI: 10.1055/s-0030-1261181


Participation of 'activated DMSO' in the one-pot transformation of aldehydes to nitriles allows the generation of a wide range of aromatic, heterocyclic, and aliphatic nitriles with water as the only byproduct. A straightforward and practical procedure is demonstrated on a multigram scale.

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Key Words

activated DMSO, nitriles, aldehydes, dehydration, catalyst

ID: J60-Y2011-2790