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Synthesis of Aminoindolizine and Quinoline Derivatives via Fe(acac)3/TBAOH-Catalyzed Sequential Cross-Coupling-Cycloisomerization Reactions

Sachin S. Patil, Sachin V. Patil, Vivek D. Bobade*

*Department of Chemistry, HPT Arts and RYK Science College, Nasik 422005, India, Email: v_bobade31rediffmail.com

S. S. Patil, S. V. Patil, V. D. Bobade, Synlett, 2011, 2379-2383.

DOI: 10.1055/s-0030-1260305 (free Supporting Information)


Abstract

A Fe(acac)3/TBAOH-catalyzed three-component coupling-cycloisomerization reaction of aldehydes, terminal alkynes, and amines provides a diverse range of heterocyclic compounds such as aminoindolizines and quinoline derivatives in good yields.


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Key Words

aminoindolizines, indolizines, quinoline derivatives, tetrabutylammonium hydroxide (TBAOH), Fe(acac)3 catalyst, cross-coupling, cycloisomerization, multicomponent reactions


ID: J60-Y2011-2850