A Novel Method for Preparing Isocyanides from N-Substituted Formamides with Chlorophosphate Compounds
Genki Kobayashi, Tateo Saito, Yoshikazu Kitano*
*Laboratory of Bio-organic Chemistry, Tokyo University of
Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan, Email:
kitayo
cc.tuat.ac.jp
G. Kobayashi, T. Saito, Y. Kitano, Synthesis, 2011, 3225-3234.
DOI: 10.1055/s-0030-1260211
Abstract
Treatment of N-substituted formamides with chlorophosphate compounds and tertiary amine bases produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides.
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Key Words
isocyanides, isonitriles, formamides, dehydration, dichlorophosphate, monochlorophosphate
ID: J66-Y2011-2910
