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Stereoselective Borylative Ketone-Diene Coupling

Hee Yeon Cho, Zhiyong Yu and James P. Morken*

*Department of Chemisty, Merkert Chemistry Center, 2609 Beacon Street, Boston College, Chestnut Hill, Massachusetts 02467, United States, Email: morkenbc.edu

H. Y. Cho, Z. Yu, J. P. Morken, Org. Lett., 2011, 13, 5267-5269.

DOI: 10.1021/ol202138v


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Abstract

Ketones, dienes, and B2(pin)2 undergo a stereoselective multicomponent coupling reaction in the presence of catalytic amounts of Ni(cod)2 and P(t-Bu)3. A subsequent oxidation furnishes 1,3-diols as the major reaction product.

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Key Words

1,3-Diols, Multicomponent Reactions

ID: J54-Y2011-2930