Organic Chemistry Portal



Palladium-Catalyzed Heck Reaction of Aryl Chlorides under Mild Conditions Promoted by Organic Ionic Bases

Hua-Jian Xu*, Yong-Qiang Zhao and Xin-Feng Zhou

*School of Medical Engineering and Anhui Key Laboratory of Controllable Chemistry Reaction & Material Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China, Email:

H.-J. Xu, Y.-Q. Zhao, X.-F. Zhou, J. Org. Chem., 2011, 76, 8036-8041.

DOI: 10.1021/jo201196a


An efficient Pd-catalyzed Heck reaction of aryl chlorides with olefins under mild conditions produces high yields of products with n-Bu4N+OAc- as base. Significantly, the temperature of the Heck reaction of diverse nonactivated aryl chlorides can be lowered to 80 C. The new reaction system tolerates a wider range of olefins.

see article for more examples

Key Words

Heck Reaction, Alkenylation

ID: J42-Y2011-2950