Palladium-Catalyzed Heck Reaction of Aryl Chlorides under Mild Conditions Promoted by Organic Ionic Bases

Hua-Jian Xu*, Yong-Qiang Zhao and Xin-Feng Zhou

*School of Medical Engineering and Anhui Key Laboratory of Controllable Chemistry Reaction & Material Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China, Email: hjxuhfut.edu.cn

H.-J. Xu, Y.-Q. Zhao, X.-F. Zhou, J. Org. Chem., 2011, 76, 8036-8041.

DOI: 10.1021/jo201196a

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Abstract

An efficient Pd-catalyzed Heck reaction of aryl chlorides with olefins under mild conditions produces high yields of products with n-Bu₄N⁺OAc^- as base. Significantly, the temperature of the Heck reaction of diverse nonactivated aryl chlorides can be lowered to 80 °C. The new reaction system tolerates a wider range of olefins.

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Key Words

Heck Reaction, Alkenylation

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ID: J42-Y2011-2950