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Palladium-Catalyzed Direct Arylation of Heteroaromatic Compounds: Improved Conditions Utilizing Controlled Microwave Heating

Mostafa Baghbanzadeh, Christian Pilger and C. Oliver Kappe*

*Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University, Graz, Heinrichstrasse 28, 8010 Graz, Austria, Email:

M. Baghbanzadeh, C.Pilger, C. O. Kappe, J. Org. Chem., 2011, 76, 8138-8142.

DOI: 10.1021/jo201516v (free Supporting Information)


A versatile microwave-assisted procedure for the palladium-catalyzed direct arylation of heterocycles by aryl bromides and heteroaryl bromides features short coupling times (10–60 min) and low catalyst loadings and allows the successful arylation of previously unreactive heterocyclic substrates.

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Key Words

Heterobiaryls, Microwave Synthesis

ID: J42-Y2011-3020