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Palladium-Catalyzed Direct Arylation of Heteroaromatic Compounds: Improved Conditions Utilizing Controlled Microwave Heating

Mostafa Baghbanzadeh, Christian Pilger and C. Oliver Kappe*

*Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University, Graz, Heinrichstrasse 28, 8010 Graz, Austria, Email: oliver.kappeuni-graz.at

M. Baghbanzadeh, C.Pilger, C. O. Kappe, J. Org. Chem., 2011, 76, 8138-8142.

DOI: 10.1021/jo201516v (free Supporting Information)


Abstract

A versatile microwave-assisted procedure for the palladium-catalyzed direct arylation of heterocycles by aryl bromides and heteroaryl bromides features short coupling times (10-60 min) and low catalyst loadings and allows the successful arylation of previously unreactive heterocyclic substrates.

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Key Words

Heterobiaryls, Microwave Synthesis


ID: J42-Y2011-3020